4.6.6. Antiulcerogenic Effect on a Model of Ethanol-Induced Ulcer in Wistar Rats

The antiulcerogenic activity of C. speciosa extract was evaluated by an experimental model of gastritis, as described by Haule et al. (2012) [28]. For the experiments, Wistar rats (150–380 g) were used. The rats were divided into 7 groups of 6 or 9 rats. Two groups were treated with 1 mL of saline orally administered (negative control without ulcer and negative control with ulcer); one group was treated with Omeprazole (40 mg/kg), a standard antiulcer, and the other groups were treated with 1 mL of plant extract (400, 80, 40, and 20 mg/kg). After 1 h, 4 mL/kg of 80% ethanol were orally administered to the rats (except for the group of negative control without ulcer) for induction of the ulcer lesions. After 4 h, all animals were sacrificed by thiopental sodic (80 mg/kg) and the stomach was removed and opened along the greater curvature and photographed. The ulcer lesion was measured with ImageJ 1.50i software to determine the size of the lesioned area in mm².