Lipopolysaccharide (LPS)-induced in vivo inflammation model

According to institutional guidelines for laboratory animals, all mice used in this study were housed in the Animal Care Facility of CHA University. This study was approved by the Institutional Animal Care and Use Committee (approval number 200159). Eight-week-old C57BL/6 female mice were provided by Orient Bio (Gapyeong, Gyeonggi, Republic of Korea), housed under temperature- and light-controlled conditions for 12 h daily, and fed ad libitum. Mice received a single dose of LPS (5 mg/kg) by intraperitoneal injection. At 12 and 24 h after LPS administration, MT-Lip with or without miRNA was injected intravenously.