2.9 Statistical analysis

Cox regression models were used to assess the relationship between gene module scores and prognosis (OS, DFS and PFI), and p <0.05 was the significance threshold in the log-rank test. Wilcox rank test was used to test the significance between two groups of continuous variables, while Kruskal Wallis rank test was used for the significance test of more than two groups. The BH method calculated the false discovery rate (FDR). All of the above analysis was done using R (version 3.6.3). Unless otherwise specified, * * * represented p <1×e-5, * * represented p <0.01 and * represented p <0.05.