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4.5.1. The MPTP Mouse Model of Parkinson’s Disease Induced by MPTP Neurotoxin

AK Anastasiia Kotliarova
AP Alexandra V. Podturkina
AP Alla V. Pavlova
DG Daria S. Gorina
AL Anastasiya V. Lastovka
OA Oleg V. Ardashov
AR Artem D. Rogachev
AI Arseniy E. Izyurov
AA Alla B. Arefieva
AK Alexander V. Kulikov
TT Tatyana G. Tolstikova
KV Konstantin P. Volcho
NS Nariman F. Salakhutdinov
YS Yulia Sidorova
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MPTP was injected intraperitoneally into mice of C57Bl/6 line every 2 h in 8 h period in one day in a dose of 20 mg/kg for a total of four doses as described before [20], and one additional dose of MPTP was injected on the 7th day. The studied compound PA96 was dissolved in saline containing 0.5% Tween 80 just before use. PA96 in a dose of 1 and 10 mg/kg or VEH was administrated per os 24 h after the last injection of MPTP. Then, PA96 or VEH was injected for 14 days in a 5-day-per-week regime for a total of fifteen doses.

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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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