FerrDb is a manually curated database for ferroptosis regulators and ferroptosis-disease associations from published journal articles [26]. The ferroptosis-related genes (FRGs) data files were screened from the FerrDb (http://www.zhounan.org/ferrdb/, accessed on 20 April 2022) based on the following criteria: 1. Knock out genes that are not expressed in humans and mice; 2. Knock out non-coding RNA. Afterward, ferroptosis-related DEGs (FRDEGs) were obtained by intersecting the screening results with DEGs.
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