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Calculation of average frequency of contact per residue for all receptors
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For the simulated GPCRs and their coupled G proteins, we calculated the average frequency (percentage of MD snapshots) per contact for those within the subset of common contacts and those made in the subset of subfamily specific contacts for the cognate G protein subfamily for each receptor. We averaged the contact frequency across all of the common and subfamily specific contacts sampled by a given GPCR:G protein complex and recorded this as the average frequency shown in Fig. 5c.
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