Malmö preventive project

The Malmö preventive project (MPP) was a community‐based lifestyle intervention program that started in the early 1970s, from which 18 240 participants were reexamined 2002–2006. Cardiovascular risk factors were evaluated and fasting plasma samples were obtained during the reexamination. From this cohort, a random sample of 5060 individuals was included in the current study. Estimated glomerular filtration rate (eGFR) was calculated from creatinine using the CKD‐EPI formula. To explore the variation in reference intervals, depending on disease burden and risk factors, we identified a healthy subcohort of 1128 subjects after excluding subjects with history of HF, atrial fibrillation, stroke, ischemic heart disease, diabetes, smoking, BMI > 30 kg/m², hypertension, and eGFR <60 mL/min/1.73 m² (Supporting Information, Figure S1 ).