Study subjects

Consecutive outpatients with H. pylori infection aged ≥ 19 years who have undergone endoscopic examination within the prior 3 months, agree to trial participation, and provide written informed consent fulfill the eligibility criteria and are invited to participate in the study. Exclusion criteria include a history of H. pylori eradication therapy; gastric surgery; abnormal liver function test or renal function test results on screening laboratory studies; antibiotic use within the prior 4 weeks; PPI use within the prior 2 weeks; histamine-2 receptor antagonist, aspirin, nonsteroidal anti-inflammatory drug, steroid, anticholinergic, prostaglandin analog, promotility drug, or sucralfate use within the prior week; use of drugs such as lovastatin, simvastatin, atorvastatin, indinavir, ritonavir, cyclosporin, terfenadine, cisapride, pimozide, astemizole, HIV protease inhibitors, and ergot alkaloids; allergic reactions to the study medications; and serious concomitant illnesses. In addition, we will exclude pregnant participants or participants who plan to become pregnant as well as patients participating in other clinical studies or who are otherwise deemed unsuitable by the researchers. Withdrawal criteria include protocol violations such as detection of eligibility violations, use of any forbidden medication during the trial that could influence the study results, or occurrence of other significant protocol violations. In addition, subjects with serious adverse events, an allergic reaction to the investigational product, withdrawal of consent, and decision to terminate for reasons of the subject’s health will be withdrawn from the study. Symptomatic patients will be allowed to use antacids on demand in the posttreatment period. Antibiotics or other medications affecting the treatment results will be prohibited during the study period.