Improve Research Reproducibility A Bio-protocol resource
Concise Method
tooltip

2.4. Procedure

ZS Zhuqing Shi
JZ Jianan Zhan
JW Jun Wei
SL Skylar Ladson-Gary
CW Chi-Hsiung Wang
PH Peter J. Hulick
SZ S. Lilly Zheng
KC Kathleen A. Cooney
WI William B. Isaacs
BH Brian T. Helfand
BK Bertram L. Koelsch
JX Jianfeng Xu
ask Ask a question
Favorite

This project is a collaboration between NorthShore University HealthSystem (NorthShore) and 23andMe. Based on the considerations of (1) consent form (23andMe can share only aggregate and deidentified data) and (2) objectivity of an ancestry-specific GRS, we developed an unbiased approach for executing the project. The NorthShore team provided the method for calculating an ancestry-specific GRS to the 23andMe team, including GRS formula, ancestry-specific risk–associated SNPs, and their OR and allele frequency in each population. The 23andMe team calculated the ancestry-specific GRS for each individual and provided the aggregated results to NorthShore.

Copyright and License information:  ©2022 The Author(s)
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Do you have any questions about this protocol?

Post your question to gather feedback from the community. We will also invite the authors of this article to respond.

post Post a Question
0 Q&A