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GL Guang Li
ML Mingjian Ling
KY Kunyi Yu
WY Wei Yang
QL Qiwen Liu
LH Lijuan He
XC Xuzi Cai
MZ Min Zhong
ZM Ziyi Mai
RS Rui Sun
YX Yuanling Xiao
ZY Zhiqiang Yu
XW Xuefeng Wang
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ART and ISMN were purchased from Energy Chemical (Shanghai, China), mPEG5000 was sourced from AVT Pharmaceutical Tech Co., Ltd (Shanghai, China), apoptosis detection kit, ROS assay kit, and NO fluorescence probe were obtained from Beyotime (Shanghai, China), and RNS fluorescence probe was provided by BestBio (Nanjing, China). The polyclonal antibody was bought from Bioss (Beijing, China). Cell culture vessels were purchased from Nest Biotechnology (Wuxi, China).

1H NMR spectra were recorded on a 400 MHz NMR spectrometer (Bruker, Switzerland). NP size and zeta potential were obtained via dynamic light scattering (DLS) analysis (Malvern, UK). The morphology and diameter were characterized using a transmission electron microscope (TEM). Drug loading rates for different NP formulations were measured using the ultraviolet (UV)-vis spectrum (Metash, UV-5500PC, China). The stability of PSSP@ART-ISMN under physiological conditions was investigated in 10% fetal bovine serum (Excell Bio, China) over the course of seven days using DLS.

Copyright and License information: The Author(s) ©2022
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