Dexamethasone (Fresenius Kabi USA) was injected IV (4 mg/kg) at 2 pm on day –1 and then at 7:30 am and 2:30 pm on day 0. Anakinra (Kineret, Swedish Orphan Biovitrum, Stockholm, Sweden) was administered subcutaneously at a 50-mg flat dose, 2 doses each on days –1 and 0 (1 hour before and 6 hours after HDAd injection). Tocilizumab (Actemra, Genentech Inc., South San Francisco, CA) was injected IV at 8 mg/kg, 2 doses each on days –1 and 0 (1 hour before and 6 hours after HDAd injection) via diluted infusions (50 mL each).
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