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Histological scoring of sections closest to the middle of the defect were done by 4 blinded investigators (CVN, CHE, RDLV, MC) using the modified O'Driscoll scoring scale. The investigators' scores were averaged for each defect so that the mean results of the four scorers will be used for comparisons. A Mann-Whitney U, non-parametric test was performed to determine statistical significance (p < 0.05) of the 3-month (n = 2 rabbits/group; n = 4 defects/group) and 12-month histological scores (n = 3 rabbits/group; n = 6 defects/group).
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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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