An initial decision tree model leading to a state transition model was used to estimate the cost per QALY gained of AP versus no AP over a time horizon of 50 years. One-way and probability sensitivity analysis and expected value of perfect information (EVPI) analysis were also conducted. We used Treeage Pro software (https://www.treeage.com) to construct the decision tree and state transition model and the Sheffield Accelerated Value of Information Tool (http://savi.shef.ac.uk/SAVI/) for the EVPI analysis.
This analysis was performed in compliance with the Consolidated Health Economic Evaluation Reporting Standard (CHEERS) guidelines for the reporting of health economic analyses.30 Ethics approval was not required for this study because it was confined to analysis of publicly available data containing no identifiable patient information.
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