A PPI network of core regulatory targets was conducted using the STRING database (https://string-db.org). The species was “Homo sapien” and confidence was 0.4. The PPI network was then imported into Cytoscape 3.8.2 software to retrieve the crucial subnetwork. The Cytohubba and CytoNCA plugin was used to select the top 20 nodes and reconstruct the crucial network.
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