Identification of Differential HCC Plasma miRNAs in 2 Datasets

Two large public datasets (The Cancer Genome Atlas (TCGA) and {"type":"entrez-geo","attrs":{"text":"GSE50013","term_id":"50013"}}GSE50013) were used to search for differential plasma miRNA expression profiles in HCC patients and healthy controls to avoid the potential bias of single-center data. The Cancer Genome Atlas miRNA expression profiling data were downloaded from the Genomic Data Commons (GDC) (https://portal.gdc.cancer.gov, accessed on April 23, 2020), (Supplementary Table 1). Likewise, {"type":"entrez-geo","attrs":{"text":"GSE50013","term_id":"50013"}}GSE50013-processed miRNA expression profiling data (both normalized miRNA profiling and clinical data) were downloaded from the Gene Expression Omnibus (GEO) database (https://www.ncbi.nlm.nih.gov, accessed on May 28, 2020) (Supplementary Table 2).