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In the present study, we estimated the average benefit brought by 650 nm LLRL compared with the control, which was calculated as follows:
where B is the benefit; Mt is the mean value of 6-month change in primary outcomes of the LLRL group if data is normally distributed, otherwise the median value would be used; and Mc is the mean value of six-month change in primary outcomes of the control group if data is normally distributed, otherwise the median value would be used.
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