BMI and smoking

At each follow-up examination, the height and weight of the SJLIFE participant was measured. BMI of survivors was calculated as weight (kg) divided by height (m) squared (kg/m²). According to the standardized classification of the World Health Organization, BMI was categorized as <18.5, 18.5 to <25.0, 25.0 to <30.0 and ≥30.0 kg/m². BMI was considered a health behaviour–related factor [^24,25]. Smoking status was assessed based on self-reported questionnaires at each follow-up visit and categorized as non-smoker versus former or current smoker. BMI and smoking status at the same or closest date of blood draw for DNAm analysis were used in the current analysis.