2.1. GEO2R Bioinformatics Analysis

A microarray dataset deposited in the Gene Expression Omnibus (https://www.ncbi.nlm.nih.gov/gds, submission date: Jan 2021) and accessioned as {"type":"entrez-geo","attrs":{"text":"GSE165004","term_id":"165004"}}GSE165004 was used to identify differentially expressed RNAs. This dataset was generated on the {"type":"entrez-geo","attrs":{"text":"GPL16699","term_id":"16699"}}GPL16699 platform and contained endometrial samples from 24 women with RPL, 24 women with UIF, and 24 fertile women at days 19–21 of the menstrual cycle. Differentially expressed RNAs in the endometrial samples between women with RPL and fertile women and between women with UIF and fertile women were, respectively, sorted using the online tool GEO2R [11] based on the R software limma package. Sorted differentially expressed RNAs must fulfill log2|fold change (FC)| > 1 and adjusted P < 0.05.