Diagnosis of normal cognition, subjective cognitive decline, mild cognitive impairment, and dementia in the history-based artificial intelligence clinical dementia diagnostic system database

Normal cognition is diagnosed as having a global CDR (Morris, 1993) score of 0. The CASI should be in the non-demented range after adjustment for age, sex, and education (Lin et al., 2002). MCI was diagnosed based on the criteria proposed by Petersen et al. (1999). It is defined as the symptomatic predementia phase of AD, thus there is a change in cognition with impairment in the CASI or MoCA tests, but without impairment in social or occupational functioning with a CDR score of 0.5 (Albert et al., 2011). The cutoff scores of MCI using the CASI after adjustment for age and education should be in the non-demented range (Lin et al., 2002). Dementia was diagnosed based on the criteria proposed by the NIA-AA (McKhann et al., 2011). Participants were considered to have dementia when having the impairments in two or more cognitive domains and a decline in daily functions with a global CDR score ≥ 0.5. IADL score < 6 or HAIADL score > 8 were applied for the operational diagnosis of functional impairment (Lawton and Brody, 1969; Morris et al., 1997). The CASI was used to define CI. The cutoff score after adjustment for age, sex, and education should be in the demented range (Lin et al., 2002).