Statistical methods for primary and secondary outcome {20a}

AD Alexandre Demoule
RD Robin Deleris
CB Côme Bureau
SL Said Lebbah
MD Maxens Decavèle
MD Martin Dres
TS Thomas Similowski
AD Agnes Dechartres
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The comparison between the two treatment groups of the mean dyspnea during the first 24 h will be performed by a Mann Whitney test taking a one-sided alpha risk of 10% to limit the risk of missing a difference. The primary outcome will be analyzed in the modified intent to treat population considering all patients randomized having received at least one dose of intervention in the group in which they will be randomized.

Quantitative variables will be compared between the two arms with a Mann-Whitney test. Categorical variables will be compared between the two arms with a chi-square test or a Fisher’s exact test as appropriate.

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