The microarray data and clinical data of GSE22762 (Herold et al., 2011a) and GSE39671 (Chuang et al., 2012), which contain 107 and 130 CLL patients, respectively, were downloaded from the Gene Expression Omnibus (GEO) database. These data were conducted by GPL570 and GPL96/GPL97. Here, 9 other datasets were also analyzed for different purposes, and the details were presented in Table 1 (Fabris et al., 2008; Stamatopoulos et al., 2009a; Stamatopoulos et al., 2009b; Giannopoulos et al., 2009; Mosca et al., 2010; Herold et al., 2011b; Trojani et al., 2011). In the meantime, the International Cancer Genome Consortium (ICGC) CLL sequencing data were extracted from the European Genome-Phenome Database (EGA).
Details of databases used in this research study.
CLL, chronic lymphocytic leukemia; PBMC, peripheral blood mononuclear cells; M-CLL, IGHV mutated CLL; U-CLL, IGHV un-mutated CLL; OS, overall survival; TTT, time-to-treatment.
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