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Prism 6.0 software (GraphPad, San Diego, CA, USA) was used to compute the statistical data. The results are expressed as the mean ± standard error of mean, and the Mann-Whitney U test was used to analyze continuous variables. The Wilcoxon matched-pairs signed rank test was applied to analyze matched or paired data collected from in vitro studies. One-way analysis of variance was performed for multiple comparisons. A P-value ≤0.05 was considered statistically significant.
Detailed methods can be found in the Online Supplementary Methods.
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