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Data analysis

HE Hannah Ellerbroek
SH Sandra A. S. van den Heuvel
AD Albert Dahan
HT Hans Timmerman
CK Cornelis Kramers
AS Arnt F. A. Schellekens
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Descriptive statistics will be used to summarize demographic variables and to analyze the baseline measures of the primary and secondary outcome parameters. The relationship between the OME of the drug at baseline and the OME of buprenorphine or methadone at follow-up be analyzed using Pearson’s r correlation. The analyses of the primary and secondary parameters will be based on superiority hypotheses and will be conducted with intention to treat analyses. Scores on the primary and secondary study outcomes will be compared between both treatment arms (between subject factor), as well as over time (within subject factor), using a linear mixed model analysis, with the scores on the outcome measures as the dependent factor.

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