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Pharmacokinetics data analysis

LZ Lingxiao Zhang
LG Liangying Gan
KL Kexin Li
PX Panpan Xie
YT Yan Tan
GW Gang Wei
XY Xiaojuan Yuan
RP Raymond Pratt
YZ Yongchun Zhou
AH Ai-Min Hui
YF Yi Fang
LZ Li Zuo
QZ Qingshan Zheng
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Population PK analysis was performed using 3 datasets, namely, M1, healthy individuals; M2, CKD-5HD patients treated with FPC dialysate; and M3, CKD-5HD patients treated with pre-dialyzer FPC (administration of FPC through pre-dialysate blood circuit for 3 h). Three separate models were established to accurately quantify the effects of covariates such as ethnic differences and to achieve the research purposes.

There are differences in PK parameter under different dosing regimens; hence, in this analysis, 3 different models were established to accurately determine the influence of ethnicity on PK parameters. All statistical analyses were performed using SAS (version 9.4, Cary, North Carolina, USA).

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