Improve Research Reproducibility A Bio-protocol resource
Concise Method
tooltip

Post-mortem MRI and global atrophy measurement

CD Carole Davoust
BP Benjamin Plas
AB Amélie Béduer
BD Boris Demain
AS Anne-Sophie Salabert
JS Jean Christophe Sol
CV Christophe Vieu
LV Laurence Vaysse
IL Isabelle Loubinoux
ask Ask a question
Favorite

Either the whole animal anaesthetized or just the brain was scanned on a 3T Achieva (Phillips) MRI scanner. Horizontal and coronal T2-weighted images were acquired (TR 2 s, TE 81 ms, impulsion angle 90°, FOV 200 mm, matrix 176 × 150, voxel size 0.34 mm × 0.34 m × 0.8 mm).

Hemispheric volume was determined using MRIcro on the horizontal slices. Hemispheric atrophy was then calculated using the following formula:

Copyright and License information: The Author(s). ©2017
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Do you have any questions about this protocol?

Post your question to gather feedback from the community. We will also invite the authors of this article to respond.

post Post a Question
0 Q&A