2.9. Evolutionary conservation analysis of active enhancers

The sequence conservation of active enhancers was assessed using the phastCons method in the UCSC genome browser (http://genome-asia.ucsc.edu/). The conserved elements were analysed in 60 vertebrates. Each element is assigned a logarithm of the odds (LOD) scores equal to its log probability under the conserved model minus its log probability under the non‐conserved model. The ‘score’ contains transformed log‐odds scores, taking values between 0 and 1000. The raw log‐odds scores are retained in the ‘name.’ Elements conservation is measured as the LOD score of phastCons elements.