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Rat pharmacokinetics studies were performed by GVK Biosciences (Hyderabad, India) as described in the Supplementary Material. Mouse samples were processed at UNSW and performed as previously published (13), with the exception that standards were prepared by spiking known concentrations of SHD865 into untreated plasma, and electrospray ionization was performed in negative mode using transitions of m/z 411.1 > 306 and 411.1 > 374.8 with a 5-min retention time to identify SHD865.
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