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The bulk RNA sequencing (RNA-seq) data as well as the phenotypic data for the CRC cases was provided by The Cancer Genome Atlas (TCGA, https://portal.gdc.cancer.gov/) database [33]. A cohort under study consisted of 434 samples from patients with colorectal cancer, comprising 383 tumor samples and 51 normal samples. GSE17536, GSE17537, and GSE38832 have been purchased from GEO database, accessible at (https://www.ncbi.nlm.nih.gov/geo/). In a new report by the TSVETKOV team [13] and The Molecular Signature Database (MSigDB) (http://www.gsea-msigdb.org/gsea/msigdb/), we chose 61 cuproptosis-related genes from them for further investigation.

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