Quantification and Statistical Analysis

Graphs represent mean values ± SEM. We represent p-values in all figures as *p≤0.05, **p≤0.01, and ***p≤0.001. We used the D’Agostino & Pearson omnibus normality test, and unpaired student’s t-test for significance (Figure 4), or one-way or two-way ANOVA with Tukey’s posthoc to test for significance (Figure 4, ​,77 and ​and8).8). We performed all statistical analyses using GraphPad Prism 6 software (GraphPad Software Inc., La Jolla, CA).