Plant material

The Lonicera japonica & Chenpi distillation extract (LCDE) was made by mixing Lonicera japonica, Taraxacum (Code Number: 00225A), Chenpi (00891A), Forsythia (00232A), and Licorice (00258A). The plants used in this study were cultivated by farmers at a specialized farm in the Jirisan Mountain of Gyeongsangnam-do, and are assigned a code number after complete identification of the material by professional identification personnel at the Animal Bio Resource Bank (http://www.abrb.or.kr). Afterwards, it was stored in the herbarium for distribution and research purposes. The Animal Biologically Active Substances Resource Bank is a nationally designated research data bank that has optimal storage conditions for the storage and distribution of research materials. These plants were washed with water, then cut into small pieces, and dried in an oven (55 °C for 72 h). Until use, the mixture plants are stored in sealing polyethylene bags with silica gel at − 20 °C.