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Annotations of the WSIs

SM Shorouk Makhlouf
NW Noorul Wahab
MT Michael Toss
AI Asmaa Ibrahim
AL Ayat G. Lashen
NA Nehal M. Atallah
SG Suzan Ghannam
MJ Mostafa Jahanifar
WL Wenqi Lu
SG Simon Graham
NM Nigel P. Mongan
MB Mohsin Bilal
AB Abhir Bhalerao
DS David Snead
FM Fayyaz Minhas
SR Shan E. Ahmed Raza
NR Nasir Rajpoot
ER Emad Rakha
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Exhaustive region and cell level annotations were performed by six experienced pathologists for supervised ML training models. Regional annotations involved invasive and in situ tumour areas, tumour associated stroma (TAS), and normal breast tissue (terminal duct lobular units) regions. Cell annotations included tumour cells with various morphologies and degrees of pleomorphism, stromal cells either fibroblasts or myofibroblasts, normal epithelial cells and TILs. Areas of necrosis, calcification and tissue/image artefacts were also annotated and excluded from the final image processing. The detailed process of image acquisition and annotation of this cohort was previously described [24].

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