GraphPad Prism software version 9.0.1 (San Diego, CA, USA) was used for statistical analysis with the methods present in the figure legends. A standard t-test with Holm–Sidak’s multiple comparisons corrections was used when comparing two groups for significance. A one-way or two-way analysis of variance (ANOVA) with post hoc Tukey’s multiple comparisons test was used to compare more than two groups. Error bars are expressed as mean ± the standard error of mean (±SEM) or mean ± standard deviation of mean (±SD) as indicated in figure legends. Significance was defined as a p-value less than 0.05.
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