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MRI ability of HMMDN-Met@PM

LC Lijuan Chong
YJ Yao-Wen Jiang
DW Dongxu Wang
PC Pengzhao Chang
KX Kai Xu
JL Jingjing Li
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The aqueous T1-weighed magnetic resonance signal was measured on a 3.0 T MR imaging system (GE 750 W). Due to MDN can respond to tumor microenvironments (TME), such as pH or GSH [18], therefore, PBS (pH 7.4), PBS (pH 5.5) and PBS (pH 5.5) containing 10 mM GSH were adopted as the different dispersants for HMMDN-Met@PM (1.05 mM Mn). The prepared dispersion of different groups was stepwisely diluted to different concentrations of Mn2+ solution (0, 0.11, 0.21, 0.31, 0.42, 0.63, 1.05 mM) for further detection. After 6 h, the T1-weighed signal of the obtained sample was collected. The T1 relaxation time in the same region of interest (Regions of interest, ROI) in each hole was measured. The abscissa was the concentration of Mn, and the ordinate was the reciprocal of the T1 relaxation time of the sample. The slope of the corresponding linear regression equation represented the T1 relaxation rate.

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