Statistical analyses

qPCR data and the parameters of the behavioral studies were analyzed with one- or two-way analysis of variance (ANOVA) with post-hoc Tukey’s test or with Wilcoxon’s test. For statistical analysis of the patch-clamp recordings, the Mann-Whitney test, the Kolmogorov-Smirnov test or Student’s t-test was used. The onset of seizures was analyzed using the Mann-Whitney test. For Western-blot analysis, the paired Student’s t-test was used. All data are expressed as the mean or geomean ± s.e.m. The levels of significance were set at *p ≤ 0.05, **p ≤ 0.01 and ***p ≤ 0.001.