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Chromosmal microarray analysis (CMA)
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The DNA samples were extracted from amniotic fluid and blood samples using TIANGEN microDNA Kit (TIANGEN, Beijing, China). Briefly, DNA was digested, ligated to adaptors, and amplified by PCR. Then, purified DNA was fragmented, biotin-labeled and hybridized to the 750K chip. Chromosome Analysis Suite (ChAS) software (Affymetrix, Santa Clara, CA) was used to analyze the raw data and visualize the results based on the GRCh38 assembly.
Copyright and License information: ©2023 Chen, Chen, Shi, Tao, Li, Zhu, Yang and Xu.
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