Forty male wild-type C57BL/6 mice, aged 8–10 weeks and weighing 22–28 g from Beijing Vital River Laboratory Animal Technology Co. were used in whole experiments. The animals were placed in cages under specific pathogen-free (SPF) conditions and nourished with a standard laboratory diet. Before starting, all experimental operations were conducted in accordance with the National Institute of Health Guide for the Care and Use of Laboratory Animals and approved by the Scientific Investigation Committee of Tianjin Medical University General Hospital.
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