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2.7. Pathway and network analysis by Ingenuity Pathway Analysis (IPA).
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Similar to GO analysis, a list of DEG (top 300) containing gene identifiers and corresponding expression values was uploaded into the IPA software (Qiagen) [16]. The “core analysis” function included in the software was used to interpret the differentially expressed data, which included biological processes, canonical pathways, upstream transcriptional regulators, and gene networks. Each gene identifier was mapped to its corresponding gene object in the Ingenuity Pathway Knowledge Base (IPKB).
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