As described in a previous study66, we defined 15 distinct chromatin states across 14 tissues and grouped them into the following seven categories: (1) promoters included TssA (Strongly active promoters/transcripts), TssAHet (Flanking active TSS without ATAC), and TssBiv (Transcribed at gene); (2) TSS-proximal transcribed regions included TxFlnk (Transcribed at gene), TxFlnkWk (Weak transcribed at gene), and TxFlnkHet (Transcribed region without ATAC); (3) enhancers included EnhA (Strong active enhancer), EnhAMe (Medium enhancer with ATAC), EnhAWk (Weak active enhancer), EnhAHet (Active enhancer no ATAC), and EnhPois (Poised enhancer); (4) repressed regions included Repr (Repressed polycomb) and ReprWk (Weak repressed polycomb); (5) quiescent regions; (6) ATAC_Is (ATAC island); (7) TssBiv (Bivalent/poised TSS).
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