Definition of chromatin status

PZ Pengju Zhao
LG Lihong Gu
YG Yahui Gao
ZP Zhangyuan Pan
LL Lei Liu
XL Xingzheng Li
HZ Huaijun Zhou
DY Dongyou Yu
XH Xinyan Han
LQ Lichun Qian
GL George E. Liu
LF Lingzhao Fang
ZW Zhengguang Wang
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As described in a previous study66, we defined 15 distinct chromatin states across 14 tissues and grouped them into the following seven categories: (1) promoters included TssA (Strongly active promoters/transcripts), TssAHet (Flanking active TSS without ATAC), and TssBiv (Transcribed at gene); (2) TSS-proximal transcribed regions included TxFlnk (Transcribed at gene), TxFlnkWk (Weak transcribed at gene), and TxFlnkHet (Transcribed region without ATAC); (3) enhancers included EnhA (Strong active enhancer), EnhAMe (Medium enhancer with ATAC), EnhAWk (Weak active enhancer), EnhAHet (Active enhancer no ATAC), and EnhPois (Poised enhancer); (4) repressed regions included Repr (Repressed polycomb) and ReprWk (Weak repressed polycomb); (5) quiescent regions; (6) ATAC_Is (ATAC island); (7) TssBiv (Bivalent/poised TSS).

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