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All experiments were conducted in accordance with the revised Declaration of Helsinki and Good Clinical Practice guidelines and were approved by the ethics committee of Osaka University Hospital (permit number 12091-6, nos. 12148 and 20043). Written informed consent was obtained from all the participants or their legal representatives. All the animal experiments were performed in compliance with the Japanese national guidelines and the guidelines of the Osaka University (permit number: Biken-AP-H21-28-0).
Copyright and License information: ©2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).
This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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