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Induction of FDM models

XW Xuejun Wang
QL Qinghong Lin
SL Shengtao Liu
XL Xiaoying Li
XK Xiehe Kong
YW Yuliang Wang
WT Weijung Ten
YH Yangyi Huang
YY Yanting Yang
JZ Jing Zhao
XM Xiaopeng Ma
XZ Xingtao Zhou
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Guinea pigs were assigned to two groups: the normal control group (NCG) and the FDM group (FDMG) (n = 21/group). All eyes in the NCG were untreated. The right eyes in the FDM group were occluded with latex balloons as translucent masks for 8 weeks as previously described [23], and the fellow eyes remained unoccluded. Throughout the entire experiment, care was taken to ensure that the right eye remained completely covered but that the animal could blink freely. The left eyes of the FDM group animals were used as contralateral controls.

Mice were also assigned to two groups: the normal control group (NCG) and the FDM group (FDMG) (n = 9/group). Monocular FDM was induced in mice as previously described [24]. Briefly, the right eyes of mice were covered with a white translucent occluder that was glued around the eyes for 4 weeks. A plastic collar was fitted around the mouse’s neck to prevent the mouse from removing the occluder.

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