2.1 Mouse models

All animal experiments in the present study were performed under the guidelines of the Institute of Animal Care and Use Committee of Konkuk University (IACUC# KU21020). The Ino80 cKO allele (Ino80^2f/2f) and Tg(MMTV-Cre) animals were obtained from the Institut Clinique de la Souris (ICS; llkirch, France) and the Jackson laboratory. Female Ino80^2f/2f mice were bred with Ino80^2f/+; MMTV-Cre males to produce littermate control (Ino80^2f/2f) and experimental (Ino80^2f/2f; MMTV-Cre) females. PCR genotyping for the Ino80 cKO allele was carried out with the following primers: 5′-AGG​CCT​TAT​TTA​GCT​CAG​GTT​GGC-3’ (forward) and 5′- CCA​CTA​CAC​ACA​GCA​GAT​ACA​CAT -3’ (reverse). The PCR amplicons for wildtype and the conditional alleles were 224 and 382 bp, respectively.