Module enrichment of misexpressed genes after the onset of psychiatric disorders

Gene expression data of brain samples from patients with schizophrenia, bipolar disorder, autism spectrum disorder or major depressive disorder and unaffected individuals were obtained from ref. 83. Genes with an adjusted P value less than 0.05 were considered misexpressed genes in a psychiatric disorder. The summary can be found in Supplementary Table 13e. The one-sided hypergeometric test was used to determine whether there was a significant overlap with individual PSD modules. The union of genes encoding PSD proteins and those expressed in the human neocortex was used as the background. The resulting nominal P values were adjusted using the Benjamini–Hochberg method.