Lead-time bias

HA Hans-Olov Adami
MB Michael Bretthauer
LE Louise Emilsson
MH Miguel A. Hernan
MK Mette Kalager
JL Jonas F. Ludvigsson
AE Anders Ekbom
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Closer surveillance of patients with IBD may entail earlier diagnosis (lead-time) of cases and overdiagnosis of colorectal cancer and that would not otherwise have surfaced clinically. Lead-time and overdiagnosis would make survival analyses which compare prognosis between IBD-related and IBD-unrelated colorectal cancer difficult to interpret.20 Therefore, the extent of colonoscopic surveillance – organized or opportunistic - should be reliably reported in all studies.

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