2.2.2. Homogeneity of Flurbiprofen Content in the Extrudates

To check the homogeneity of the flurbiprofen content in the formulations, the extrudate thread was cut into three segments of equal length, representing the start, middle and end of the extrusion process. Samples from each segment (n = 3), with a weight of approx. 1 mg apiece, were transferred into 10 mL volumetric flasks, filled to volume with mobile phase and dissolved by ultrasonication for at least 30 min. After appropriate dilution with mobile phase (1:1), the samples were analyzed by HPLC. For the API content, the limit of acceptable variation was set at ±5%.