This study was approved by the Institutional Review Board, Faculty of Dentistry/Faculty of Pharmacy, Mahidol University (MU-DT/PY-IRB 2019/050.3107 and MU-DT/PY-IRB 2019/041.0307). This study was in full compliance with International Guideline for Human Research Protection including the Helsinki Declaration, the Belmont Report, CIOMS Guideline and the International Conference on Harmonization in Good Clinical Practice. All subjects provided a signed inform consent to participate in the study.
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