Improve Research Reproducibility A Bio-protocol resource
Concise Method
tooltip

Modeling platform and data collection

CS Chaozhuang Shen
WS Wenxin Shao
WW Wenhui Wang
HS Hua Sun
XW Xiaohu Wang
KG Kuo Geng
XW Xingwen Wang
HX Haitang Xie
ask Ask a question
Favorite

Whole‐body PBPK (WB‐PBPK) models of LEV and the metabolite ucb L057 in adults, hepatic and renal impairment, and elderly populations were developed using the population‐based PBPK simulator PK‐Sim (version 11, Open Systems Pharmacology Suite, https://www.open‐systems‐pharmacology.org/), using the Monte Carlo algorithm for parameter identification. Visualization of published clinical data using GetData Graph Digitizer (version 2.25.0.32, S. Fedorov, http://www.getdata‐graph‐digitizer.com/) software. Plots were generated in GraphPad Prism 8. PK parameters were calculated using noncompartmental model analysis in Phoenix WinNonlin 8.1 software (Pharsight, Mountain View, CA; https://www.certara.com/software/phoenix‐winnonlin/).

Copyright and License information:  ©2023 The Authors. published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.
This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

Do you have any questions about this protocol?

Post your question to gather feedback from the community. We will also invite the authors of this article to respond.

post Post a Question
0 Q&A