Datasets

ZC Zuobing Chen
WC Wenxiu Cao
JL Jiangti Luo
ZA Zeinab Abdelrahman
QL Qiqi Lu
HW Huafen Wang
XW Xiaosheng Wang
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Gene expression profiles of 537 KIRC patients were downloaded from The Cancer Genome Atlas (TCGA), along with their clinical data from the cBioPortal for Cancer Genomics (https://www.cbioportal.org/). From the genomic data commons (GDC) data portal (https://portal.gdc.cancer.gov/), we downloaded profiles of somatic mutations (“maf” file) and somatic copy number alterations (SCNAs) (“SNP6” files) for the 537 TCGA-KIRC patients. Furthermore, we acquired gene expression profiles and clinical data for three KIRC cohorts from the NCBI gene expression omnibus (GEO) (https://www.ncbi.nlm.nih.gov/geo/), with accession ID GSE29609, GSE40435, and GSE73731. The datasets are summarized in Supplementary Table S1 . Prior to performing subsequent analyses, we conducted normalization of all RNA sequencing (RNA-seq) gene expression values through log2(TPM+1) transformation.

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