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The paraffin sections of liver tissues were stained with hematoxylin and eosin, Masson and Sirius Red staining. Frozen liver sections were used to stain with oil red O for visualizing the lipid accumulation. Masson and Sirius's Red staining were for evaluating the severity of fibrosis. Immunohistochemical (IHC) staining and immunofluorescence (IF) were described in the supplementary materials. Histological images were acquired under a microscope.

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