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TK Topias Karjula
AN Anne Niskakangas
OM Olli Mustonen
IP Iiris Puro
HE Hanna Elomaa
MA Maarit Ahtiainen
TK Teijo Kuopio
JM Jukka-Pekka Mecklin
TS Toni T. Seppälä
EW Erkki-Ville Wirta
ES Eero Sihvo
FY Fredrik Yannopoulos
OH Olli Helminen
JV Juha P. Väyrynen
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Royal College of Surgeons Charlson Score (RCS) was used for comorbidity classification [21]. The cancer under treatment was included as one comorbidity. Disease-free interval (DFI) was defined as the interval from surgery of CRC tumour to the date of detection of the first pulmonary metastasis. Pulmonary metastases that were detected less than 6 months after primary cancer treatment were deemed as synchronous and metachronous if otherwise.

The primary outcome of the study was 5-year overall survival from the date of pulmonary metastasectomy to death due to any cause before the end of follow-up. Only 1 patient died of another cause than cancer; therefore, cancer-specific survival was not analysed.

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