2.4.2. Postoperative pain model

This model consisted in an intraoral incision as previously described (Araya et al., 2020b; Urata et al., 2015). The animals were anesthetized with a mixture of ketamine and xylazine (50 and 10 mg/kg, respectively, i.p.) and an incision was made on the right side of the intra oral mucosa (about 2 mm deep and 1 mm long). The incision was sutured with a 4.0 silk thread. The sham group was subjected to the same procedures, excepted for the incision.